Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 27 Researches
4.9
USERS' SCORE
Good
Based on 84 Reviews
8.6
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
7
We set out to investigate whether magnesium citrate could be an effective remedy for those who experience bothersome leg cramps, particularly at night. In our study, we used a randomised, double-blind, cross-over, placebo-controlled design to ensure reliable results. Participants suffering from regular leg cramps were recruited and given either magnesium citrate or a matching placebo over six weeks.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
Our findings revealed that those who began the trial with the placebo experienced an average reduction in cramps when taking magnesium, with a median of 5 cramps compared to 9 on the placebo. Moreover, a notable percentage of participants felt that the magnesium treatment had indeed helped them, with 78% reporting benefits, as opposed to 54% who felt the placebo was effective.
While these results suggest that magnesium may have a positive impact, it’s essential to mention that the impact on cramp severity and duration wasn’t significantly different between the two groups. Additionally, some participants did report experiencing diarrhoea as a side effect of magnesium. Overall, we believe magnesium shows promise in alleviating nocturnal leg cramps and recommend further research to fully evaluate its effectiveness.
Read More
Most Useful Reviews
10
Leg cramps relief
A wonderful complex of minerals! I’m amazed by the effect! At 39, my legs often hurt and felt heavy after walking. After a month of taking this, the pain disappeared completely! I take it in cycles, drinking for a month and then resting for a month. I hope my honest feedback helps others.
Read More
8.3
Cramps improvement
After two months of taking these vitamins, I'm satisfied. They have improved my muscle tone and eliminated my calf cramps, as prescribed by my doctor.
Read More
7.5
Fewer cramps
The large pack contains 100 tablets, and I found the effect after a month. My leg cramps and knee pain have decreased, so I plan to take it again in autumn.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 27 Researches
4.9
- All Researches
9.5
We observed an interesting case regarding the effects of calcium treatment on leg cramps related to a chemotherapy drug called oxaliplatin. In this case, a 62-year-old woman undergoing palliative treatment for stage IV colon cancer experienced acute neurotoxicity symptoms. Notably, thirty minutes after her first infusion of oxaliplatin, which she received in her left arm, she developed cramps and paresthesia in her right leg.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
As part of her treatment for these symptoms, intravenous calcium gluconate was administered alongside magnesium sulfate. This combination helped alleviate her leg cramping and associated symptoms within three hours. However, while calcium was part of the treatment regimen, it is important to note that its isolated effectiveness on leg cramps is unclear due to its concurrent administration with magnesium.
Consequently, while we saw improvement in the patient's symptoms, it is difficult to attribute these results solely to calcium. Instead, it suggests that magnesium might be playing a significant role as well. Future investigations could help clarify the specific contributions of calcium in treating leg cramps related to neurotoxicity and other conditions.
Read More
9.5
We explored the effects of magnesium treatment in a unique case involving a 62-year-old woman with stage IV colon cancer undergoing oxaliplatin therapy. Shortly after her first infusion, we observed that she experienced significant neurological symptoms, including right hemibody paresthesia, muscle cramping in her right calf, and dysphonia.
To address these symptoms, she was administered intravenous magnesium sulfate along with calcium gluconate. Remarkably, within three hours, all her symptoms resolved. While this case suggests that magnesium can provide relief from cramps and other neurological side effects, it is important to note that magnesium was used in conjunction with other medications, making it challenging to assess its isolated effectiveness.
For future doses, the oxaliplatin was adjusted by reducing the dose and extending the infusion duration, which minimized her symptoms to occasional mild paresthesia. In summary, while magnesium showed promise in this case, further research is needed to determine its specific impact on leg cramps in a clearer, more controlled manner.
To address these symptoms, she was administered intravenous magnesium sulfate along with calcium gluconate. Remarkably, within three hours, all her symptoms resolved. While this case suggests that magnesium can provide relief from cramps and other neurological side effects, it is important to note that magnesium was used in conjunction with other medications, making it challenging to assess its isolated effectiveness.
For future doses, the oxaliplatin was adjusted by reducing the dose and extending the infusion duration, which minimized her symptoms to occasional mild paresthesia. In summary, while magnesium showed promise in this case, further research is needed to determine its specific impact on leg cramps in a clearer, more controlled manner.
Read More
9
Calcium dobesilate reduces leg cramps
We examined the benefits of calcium dobesilate for patients suffering from chronic venous insufficiency (CVI), particularly focusing on how it impacts symptoms like leg cramps. In a systematic evaluation of ten different clinical trials involving 778 patients, we compared the effects of calcium dobesilate to a placebo.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Our analysis found that calcium dobesilate significantly reduced night cramps, helping patients nearly twice as much as those who received a placebo. The number needed to treat for this relief was calculated to be 8, indicating that for every eight patients treated with calcium dobesilate, one experienced noticeable improvement.
Moreover, patients also reported less discomfort, with a number needed to treat of 4 for that symptom. Interestingly, we noted that those with more severe symptoms experienced even greater relief, suggesting that calcium dobesilate is particularly effective for patients with advanced CVI. However, both doses tested—1,000 mg and 1,500 mg—proved equally effective, which is good news as it suggests that a lower dose might suffice.
Additionally, we found that adverse events were not significantly different from the placebo group, indicating a favorable safety profile. While calcium dobesilate shows promise, we acknowledge the need for further studies to solidify these findings and explore its efficacy in various CVI stages.
Read More
9
Magnesium oxide treats leg cramps
We conducted a study to evaluate how effective magnesium oxide monohydrate (MOMH) is in treating nocturnal leg cramps (NLC). This was a randomized, double-blind, placebo-controlled trial involving multiple centers in Ukraine, where participants took either MOMH or a placebo nightly for 60 days.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Our focus was on measuring the frequency and duration of cramps, the pain they caused, and how they affected sleep quality and overall life satisfaction. We used thorough statistical methods to compare the results between the two groups.
The findings indicated that MOMH is both effective and safe for individuals dealing with NLC. Participants reported improvements in their symptoms, demonstrating that this magnesium supplement can play a helpful role in managing nocturnal leg cramps.
Read More
9
We sought to understand the effectiveness of oral magnesium in treating leg cramps experienced by pregnant women. Our study was well-structured, involving a double-blind, randomized, placebo-controlled design. It included 86 healthy pregnant women between 14 to 34 weeks of gestation who encountered leg cramps at least twice a week, and we followed them over a four-week period.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
At the end of the study, we discovered that the women taking magnesium bisglycinate chelate (300 mg per day) reported a significant reduction in cramp frequency—86% experienced at least a 50% drop compared to only 60.5% of those taking the placebo. Additionally, those on magnesium also noted a notable decrease in cramp intensity, with 69.8% achieving a similar improvement versus just 48.8% in the placebo group.
Encouragingly, we found no major side effects reported in either group, such as nausea or diarrhea. Our findings suggest that magnesium supplements can effectively reduce both the frequency and severity of leg cramps during pregnancy, offering a potential treatment option for women dealing with this common issue.
Read More
User Reviews
USERS' SCORE
Good
Based on 84 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Leg cramps relief
A wonderful complex of minerals! I’m amazed by the effect! At 39, my legs often hurt and felt heavy after walking. After a month of taking this, the pain disappeared completely! I take it in cycles, drinking for a month and then resting for a month. I hope my honest feedback helps others.
Read More
8.3
Cramps improvement
After two months of taking these vitamins, I'm satisfied. They have improved my muscle tone and eliminated my calf cramps, as prescribed by my doctor.
Read More
7.5
Fewer cramps
The large pack contains 100 tablets, and I found the effect after a month. My leg cramps and knee pain have decreased, so I plan to take it again in autumn.
Read More
8.3
Reduced leg cramps
The doctor recommended I drink this at night during a stressful period in my life. I started sleeping better, and my leg cramps have eased. It does take about 10 days to see the benefits, particularly with acne. Overall, I've noticed positive effects following two weeks of use.
Read More
10
Health improvement
Calcium, magnesium, and zinc are essential for health, especially for bones and muscles. After taking this complex, my leg cramps have reduced significantly, and I believe my overall health has improved as well, including better sleep. I will continue taking it regularly.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sasidharan Pillai S, Reyes M, Jüppner H, Topor LS. Growth Hormone Deficiency in an Adolescent With Pseudohypoparathyroidism Type 1B. JCEM Case Rep. 2024;2:luae152. doi:10.1210/jcemcr/luae152
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3
- Mansouri A, Mirghafourvand M, Charandabi SMA, Najafi M. The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. J Res Med Sci. 2017;22:24. doi:10.4103/1735-1995.200271
- Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD010655.pub2
- Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. doi:10.1177/1078155209355849
- Ciapponi A, Laffaire E, Roqué M. Calcium dobesilate for chronic venous insufficiency: a systematic review. Angiology. 2004;55:147.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2000;2002:CD000121.
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3
- Mansouri A, Mirghafourvand M, Charandabi SMA, Najafi M. The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. J Res Med Sci. 2017;22:24. doi:10.4103/1735-1995.200271
- Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, et al. A randomized, double-blind, placebo-controlled, multicenter study assessing the efficacy of magnesium oxide monohydrate in the treatment of nocturnal leg cramps. Nutr J. 2021;20:90. doi:10.1186/s12937-021-00747-9
- Liu J, Song G, Zhao G, Meng T. Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwan J Obstet Gynecol. 2021;60:609. doi:10.1016/j.tjog.2021.05.006
- Luo L, Zhou K, Zhang J, Xu L, Yin W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2020;12:CD010655. doi:10.1002/14651858.CD010655.pub3
- Garrison SR, Korownyk CS, Kolber MR, Allan GM, Musini VM, et al. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020;9:CD009402. doi:10.1002/14651858.CD009402.pub3
- Araújo CAL, Lorena SB, Cavalcanti GCS, Leão GLS, Tenório GP, et al. Oral magnesium supplementation for leg cramps in pregnancy-An observational controlled trial. PLoS One. 2020;15:e0227497. doi:10.1371/journal.pone.0227497
- Sebo P, Haller D, Cerutti B, Maisonneuve H. A prospective observational study of the main features of nocturnal leg cramps in primary care. Swiss Med Wkly. 2019;149:w20048. doi:10.4414/smw.2019.20048
- Roguin Maor N, Alperin M, Shturman E, Khairaldeen H, Friedman M, et al. Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2017;177:617. doi:10.1001/jamainternmed.2016.9261
- Zhou K, West HM, Zhang J, Xu L, Li W. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD010655.pub2
- Sebo P, Cerutti B, Haller DM. Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Fam Pract. 2014;31:7. doi:10.1093/fampra/cmt065
- Garrison SR, Allan GM, Sekhon RK, Musini VM, Khan KM. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2012;2012:CD009402. doi:10.1002/14651858.CD009402.pub2
- Supakatisant C, Phupong V. Oral magnesium for relief in pregnancy-induced leg cramps: a randomised controlled trial. Matern Child Nutr. 2015;11:139. doi:10.1111/j.1740-8709.2012.00440.x
- Garrison SR, Birmingham CL, Koehler BE, McCollom RA, Khan KM. The effect of magnesium infusion on rest cramps: randomized controlled trial. J Gerontol A Biol Sci Med Sci. 2011;66:661. doi:10.1093/gerona/glq232
- Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280. doi:10.1177/1078155209355849
- Roffe C, Sills S, Crome P, Jones P. Randomised, cross-over, placebo controlled trial of magnesium citrate in the treatment of chronic persistent leg cramps. Med Sci Monit. 2002;8:CR326.
- Young GL, Jewell D. Interventions for leg cramps in pregnancy. Cochrane Database Syst Rev. 2002.
- Frusso R, Zárate M, Augustovski F, Rubinstein A. Magnesium for the treatment of nocturnal leg cramps: a crossover randomized trial. J Fam Pract. 1999;48:868.
- Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol. 1995;173:175.
